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Enzalutamide in Combination with Abiraterone Acetate in Bone Metastatic Castration-resistant Prostate Cancer Patients

Authors :
Efstathiou, Eleni
Titus, Mark
Wen, Sijin
Troncoso, Patricia
Hoang, Anh
Corn, Paul
Prokhorova, Ina
Araujo, John
Dmuchowski, Carl
Melhem-Bertrandt, Amal
Patil, Shiva
Logothetis, Christopher J.
Source :
European Urology Oncology; February 2020, Vol. 3 Issue: 1 p119-127, 9p
Publication Year :
2020

Abstract

It is hypothesised that cotargeting the androgen receptor (AR) and paracrine androgen biosynthesis with enzalutamide and abiraterone acetate in metastatic castration-resistant prostate cancer (mCRPC) will dissipate adaptive feedback loops observed with either agent alone.

Details

Language :
English
ISSN :
25889311
Volume :
3
Issue :
1
Database :
Supplemental Index
Journal :
European Urology Oncology
Publication Type :
Periodical
Accession number :
ejs52327714
Full Text :
https://doi.org/10.1016/j.euo.2019.01.008