Epidemiology of Cholangiocarcinoma; United States Incidence and Mortality Trends

•Cholangiocarcinoma is an aggressive malignancy with few available studies assessing incidence and mortality.•Cholangiocarcinoma incidence rates have significantly increased over the study period (2000-2015).•Cholangiocarcinoma mortality increased significantly over the study period but decreased after 2013.•Incidence and mortality of cholangiocarcinoma were increasing in the study period with significant observed disparities based on race and gender.