[3+2] Cycloaddition of Trifluoromethylated N‐Acylhydrazones with Azomethine Ylides: Synthesis of Trifluoromethylated Imidazolidines

Trifluoromethylated N‐acylhydrazones are used as dipolarophiles to perform 1,3‐dipolar cycloadditions with azomethine ylides to afford trifluoromethylated 1,2,4,5‐tetrasubstituted imidazolidines in good yields under mild conditions. The role switch of the trifluoromethylated N‐acylhydrazones demonstrates that they are versatile trifluoromethyl building blocks for CF3‐containing heterocycles. TrifluoromethylatedN‐acylhydrazonesare used as dipolarophiles to perform 1,3‐dipolar cycloaddition with azomethine ylides to afford trifluoromethylated 1,2,4,5‐tetrasubstituted imidazolidines in good yields under mild conditions.