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Tissue damage from neutrophil-induced oxidative stress in COVID-19
- Source :
- Nature Reviews Immunology; September 2020, Vol. 20 Issue: 9 p515-516, 2p
- Publication Year :
- 2020
-
Abstract
- The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
Details
- Language :
- English
- ISSN :
- 14741733
- Volume :
- 20
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Nature Reviews Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs53925603
- Full Text :
- https://doi.org/10.1038/s41577-020-0407-1