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A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia

Authors :
Ballotta, L.
M. Trisolini, S.
P. Iori, A.
La Rocca, U.
Micozzi, A.
Gentile, G.
De Giacomo, T.
Guarini, A.
Foà, R.
Capria, S.
Source :
Case Reports in Hematology; 2020, Vol. 2020 Issue: 1
Publication Year :
2020

Abstract

The occurrence of acute myeloid leukemia (AML) within six months from a diagnosis of breast cancer (BC) is rarely reported in the literature, and it is associated with a poor prognosis. We report herein the case of a 40-year-old woman referred to our centre affected by BC and simultaneous AML. The patient proved refractory to first line therapy and achieved complete remission (CR) with a clofarabine-based regimen followed by allogeneic stem cell transplantation (ASCT). Both during salvage chemotherapy and after ASCT, the patient presented severe infectious complications ( acute cholecistytis and Nocardia pneumonia, respectively) treated with surgery, and currently she is alive in CR for both diseases after 29 months of follow-up. The case highlights the importance of a diagnostic assessment of any unexplained cytopenia in association with solid neoplasia under treatment, underlining the feasibility and priority of a timely treatment of the haematological neoplasm in order to achieve long-term survival.

Details

Language :
English
ISSN :
20906560 and 20906579
Volume :
2020
Issue :
1
Database :
Supplemental Index
Journal :
Case Reports in Hematology
Publication Type :
Periodical
Accession number :
ejs54058450
Full Text :
https://doi.org/10.1155/2020/8893185