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Solution and Solid-Supported Synthesis of 3,4,5-Trisubstituted 1,2,4-Triazole-Based Peptidomimetics
- Source :
- Organic Letters; November 2003, Vol. 5 Issue: 23 p4465-4468, 4p
- Publication Year :
- 2003
-
Abstract
- <UFIGR ID="ol035778en00001">3,4,5-Trisubstituted 1,2,4-triazoles were synthesized in solution from various thioamides and hydrazides in smooth experimental conditions leading to peptidomimetic scaffolds. This strategy was found to be compatible with the usual peptide synthesis protecting groups. This methodology was then applied on solid support by anchoring α-amino acids through their amino function to an activated carbonate resin.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 5
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs5414597