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Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
- Source :
- Chinese Chemical Letters; March 2021, Vol. 32 Issue: 3 p1020-1024, 5p
- Publication Year :
- 2021
-
Abstract
- A series of novel S-DACO derivatives were designed by structure-based linker optimization strategy. Most compounds showed potential activities against HIV-1 with IC50values ranging from 7.55 μmol/L to 0.018 μmol/L. Preliminary SAR and molecular modeling of these novel congeners were investigated.
Details
- Language :
- English
- ISSN :
- 10018417
- Volume :
- 32
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Chinese Chemical Letters
- Publication Type :
- Periodical
- Accession number :
- ejs54331332
- Full Text :
- https://doi.org/10.1016/j.cclet.2020.09.035