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Clinical Outcomes in Patients with FLT3-ITD-Mutated Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Hematopoietic Stem Cell Transplantation after Quizartinib or Salvage Chemotherapy in the QuANTUM-R Trial

Authors :
Ganguly, Siddhartha
Cortes, Jorge E.
Krämer, Alwin
Levis, Mark J.
Martinelli, Giovanni
Perl, Alexander E.
Russell, Nigel H.
Arunachalam, Meena
Santos, Cedric Dos
Gammon, Guy
Lesegretain, Arnaud
Mires, Derek E.
Pham, Hoang
Wang, Yibin
Khaled, Samer K.
Source :
Biology of Blood and Marrow Transplantation (Science Direct); 20240101, Issue: Preprints
Publication Year :
2024

Abstract

•Quizartinib enabled more patients to undergo hematopoietic stem cell transplantation (HSCT) versus chemotherapy.•Continuation of quizartinib after HSCT was tolerable, with no new safety signals.•Quizartinib before and after HSCT may confer clinical benefits in relapsed/refractory FLT3-ITD acute myelogenous leukemia.

Details

Language :
English
ISSN :
10838791 and 15236536
Issue :
Preprints
Database :
Supplemental Index
Journal :
Biology of Blood and Marrow Transplantation (Science Direct)
Publication Type :
Periodical
Accession number :
ejs54331956
Full Text :
https://doi.org/10.1016/j.bbmt.2020.09.036