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A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae

Authors :
Stamsås, Gro Anita
Restelli, Marine
Ducret, Adrien
Freton, Céline
Garcia, Pierre Simon
Håvarstein, Leiv Sigve
Straume, Daniel
Grangeasse, Christophe
Kjos, Morten
Source :
mBio; October 2020, Vol. 11 Issue: 5
Publication Year :
2020

Abstract

Penicillin-binding proteins (PBPs), the proteins catalyzing the last steps of peptidoglycan assembly, are critical for bacteria to maintain cell size, shape, and integrity. PBPs are consequently attractive targets for antibiotics. Resistance to antibiotics in Streptococcus pneumoniae(the pneumococcus) are often associated with mutations in the PBPs. In this work, we describe a new protein, CozEb, controlling the cell size of pneumococcus. CozEb is a highly conserved integral membrane protein that works together with other proteins to regulate PBPs and peptidoglycan synthesis. Deciphering the intricate mechanisms by which the pneumococcus controls peptidoglycan assembly might allow the design of innovative anti-infective strategies, for example, by resensitizing resistant strains to PBP-targeting antibiotics.

Details

Language :
English
ISSN :
21612129 and 21507511
Volume :
11
Issue :
5
Database :
Supplemental Index
Journal :
mBio
Publication Type :
Periodical
Accession number :
ejs54507807
Full Text :
https://doi.org/10.1128/mBio.02461-20