New Bromotyrosine Derivatives from an Association of Two Sponges, Jaspis wondoensis and Poecillastra wondoensis

Three new bromotyrosine derivatives (<BO>4</BO>−<BO>6</BO>) were isolated from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis, along with the previously described (E,E)-psammaplin A (<BO>1</BO>), (E,Z)-psammaplin A (<BO>2</BO>), psammaplin D (<BO>3</BO>), bisaprasin (<BO>7</BO>), and (3-bromo-4-hydroxyphenyl)acetonitrile (<BO>8</BO>). The structures of the new compounds were established on the basis of NMR and MS spectroscopic analysis. The compounds <BO>1</BO>, <BO>3</BO>, and <BO>5</BO>−<BO>7</BO> displayed significant cytotoxicity against human lung (A549), ovarian (SK-OV-3), skin (SK-MEL-2), CNS (XF498), and colon (HCT15) cancer cell lines. Compounds <BO>3</BO>−<BO>7</BO> were further evaluated for antibacterial activity against methicillin- or ofloxacin-resistant Staphylococcus strains. Compound <BO>4</BO> exhibited more potent antibacterial activity than meropenem against several strains.