The efficacies of non-bismuth containing quadruple therapies in the treatment of first-line anti-Helicobacter pyloriacross 4-year time interval with changing antibiotics resistance

Non-bismuth containing quadruple therapy (concomitant therapy) is an alternative treatment for Helicobacter pylori (H. pylori)eradication with increasing clarithromycin-resistant strains over times. This study compared the efficacies of non-bismuth containing quadruple therapy (concomitant therapy) in the treatment of first-line anti-Helicobacter Pyloribetween two time intervals (January 2013 to June 2014 and June 2016 to December 2017).