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MicroRNA-506-3p increases the response to PARP inhibitors and cisplatin by targeting EZH2/β-catenin in serous ovarian cancers

Authors :
Sun, Yue
Wu, Jing
Dong, Xiaoying
Zhang, Jingzi
Meng, Chao
Liu, Guoyan
Source :
Translational Oncology; February 2021, Vol. 14 Issue: 2
Publication Year :
2021

Abstract

•EZH2 is considered as a direct target of miR-506-3p.•MiR-506-3p overexpression decreased the level of β-catenin.•MiR-506-3p increases response to PARP inhibitors and cisplatin in serous ovarian cancer by targeting EZH2/β-catenin pathway.

Details

Language :
English
ISSN :
19447124 and 19365233
Volume :
14
Issue :
2
Database :
Supplemental Index
Journal :
Translational Oncology
Publication Type :
Periodical
Accession number :
ejs54840468
Full Text :
https://doi.org/10.1016/j.tranon.2020.100987