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Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort

Authors :
Vallet-Pichard, Anais
Correas, Jean-Michel
Dorival, Celine
Zoulim, Fabien
Tran, Albert
Bourlière, Marc
Calès, Paul
Guyader, Dominique
Bronowicki, Jean-Pierre
Larrey, Dominique
Hezode, Christophe
Loustaud-Ratti, Veronique
Gournay, Jerome
de Ledinghen, Victor
Asselah, Tarik
Ganne, Nathalie
Metivier, Sophie
Chazouillères, Olivier
Leroy, Vincent
Rosa, Isabelle
Samuel, Didier
Mathurin, Philippe
Cagnot, Carole
Fontaine, Helene
Carrat, Fabrice
Pol, Stanislas
Bonnet, Delphine
Payssan-Sicart, Virginie
Pomes, Chloe
Bailly, François
Beaudoin, Marjolaine
Giboz, Dominique
Hartig-Lavie, Kerstin
Maynard, Marianne
Billaud, Eric
Boutoille, David
Cavellec, Morane
Cheraud-Carpentier, Marjorie
Hubert, Isabelle
Benhida, Jaouad
Lannes, Adrien
Lunel, Françoise
Oberti, Frédéric
Boyer, Nathalie
Giuily, Nathalie
Castelnau, Corinne
Scoazec, Giovanna
Chibah, Aziza
Keser, Sylvie
Bonardi, Karim
Vallet-Pichard, Anaïs
Sogni, Philippe
Foucher, Juliette
Hiriart, Jean-Baptiste
Wilson, Amy
Shili, Sarah
Chermak, Faiza
Ansaldi, Christelle
Amara, Nisserine Ben
Chouquet, Laëtitia
De Luca, Emilie
Oules, Valérie
Anty, Rodolphe
Gelsi, Eve
Truchi, Régine
Luckina, Elena
Messaoudi, Nadia
Moussali, Joseph
De Dieuleveult, Barbara
Labarriere, Damien
Poter, Pascal
Ahmed, Si Nafa Si
Grando-Lemaire, Véronique
Nahon, Pierre
Bourcier, Valérie
Brulé, Séverine
Stalhberger, Thomas
Jezequel, Caroline
Brener, Audrey
Laligant, Anne
Rabot, Aline
Renard, Isabelle
Baumert, Thomas F.
Dofföel, Michel
Mutter, Catherine
Simo-Noumbissie, Pauline
Razi, Esma
Barraud, Hélène
Bensenane, Mouni
Nani, Abdelbasset
Hassani-Nani, Sarah
Bernard, Marie-Albertine
Pageaux, Georges-Philippe
Bismuth, Michael
Caillo, Ludovic
Faure, Stéphanie
Ripault, Marie-Pierre
Bureau, Christophe
Peron, Jean Marie
Robic, Marie-Angèle
Tarallo, Léa
Faure, Marine
Froissart, Bruno
Hilleret, Marie-Noelle
Zarski, Jean-Pierre
Goria, Odile
Grard, Victorien
Montialoux, Hélène
François, Muriel
Ouedraogo, Christian
Pauleau, Christelle
Varault, Anne
Andreani, Tony
Angoulevant, Bénédicte
Chevance, Azeline
Serfaty, Lawrence
Antonini, Teresa
Coilly, Audrey
Vallée, Jean-Charles Duclos
Tateo, Mariagrazia
Bonny, Corinne
Brigitte, Chanteranne
Lamblin, Géraldine
Muti, Léon
Babouri, Abdenour
Filipe, Virginie
Babouri, Abdenour
Filipe, Virginie
Barrault, Camille
Costes, Laurent
Hagège, Hervé
Merbah, Soraya
Carrier, Paul
Debette-Gratien, Maryline
Jacques, Jérémie
Lassailly, Guillaume
Artu, Florent
Canva, Valérie
Dharancy, Sébastien
Louvet, Alexandre
Latournerie, Marianne
Bardou, Marc
Mouillot, Thomas
Bacq, Yannick
Barbereau, Didier
Nicolas, Charlotte
Chevalier, Caroline
Archambeaud, Isabelle
Habes, Sarah
Amara, Nisserine Ben
Botta-Fridlund, Danièle
Saillard, Eric
Lafrance, Marie-Josée
Source :
Clinics and Research in Hepatology and Gastroenterology; January 2021, Vol. 45 Issue: 1
Publication Year :
2021

Abstract

•Our blinded analysis of HCC recurrence following “curative” treatment:•Argues against the “curative” efficacy of the first treatment of HCC in one third of patients.•Evidences that DAA therapy has no significant impact on the severity or progression of HCC recurrence.•Evidences that DAA therapy does not impact overall survival and could be considered in cirrhotic patients with prior history of HCC.

Details

Language :
English
ISSN :
22107401
Volume :
45
Issue :
1
Database :
Supplemental Index
Journal :
Clinics and Research in Hepatology and Gastroenterology
Publication Type :
Periodical
Accession number :
ejs54923532
Full Text :
https://doi.org/10.1016/j.clinre.2020.04.022