Proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or human Klebsiella pneumoniaestrain

Authors :: Krieger, Ann-Kathrin
Knappe, Daniel
Öhlmann, Sophie
Mayer, Leonie
Eder, Ines B.
Köller, Gábor
Hoffmann, Ralf
Rieckmann, Karoline
Baums, Christoph Georg
Source :: Journal of Global Antimicrobial Resistance; March 2021, Vol. 24 Issue: 1 p127-135, 9p
Publication Year :: 2021
Abstract: •New model for antimicrobial treatment of Klebsiella pneumoniaesepticaemia.•The apidaecin Api137 mediates killing of K. pneumoniaein porcine blood ex vivo.•Cytotoxicity and TNFα induction of Api137 treatment are comparable with cefquinome.

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