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Impact of Novel Targeted Therapies and Cytogenetic Risk Groups on Outcome After Allogeneic Transplantation for Adult ALL

Authors :
Abdel Rahman, Zaid H.
Heckman, Michael G.
Miller, Kevin
Alkhateeb, Hassan
Patnaik, Mrinal S.
Sproat, Lisa Z.
Jiang, Liuyan
Roy, Vivek
Murthy, Hemant S.
Ayala, Ernesto
Hogan, William J.
Greipp, Patricia T.
Kharfan-Dabaja, Mohamed A.
Litzow, Mark R.
Foran, James M.
Source :
Transplantation and Cellular Therapy; February 2021, Vol. 27 Issue: 2 p165.e1-165.e11, 14861p
Publication Year :
2021

Abstract

•CD20+, Ph-like, and therapy-related ALL are novel high-risk subgroups in adults.•Allogeneic transplantation offsets the poor prognosis associated with these subgroups.•Targeted immunotherapies do not seem to independently predict for post-transplant outcomes.•Maintenance strategies are needed to reduce relapse post-transplant.

Details

Language :
English
ISSN :
26666375 and 26666367
Volume :
27
Issue :
2
Database :
Supplemental Index
Journal :
Transplantation and Cellular Therapy
Publication Type :
Periodical
Accession number :
ejs55204495
Full Text :
https://doi.org/10.1016/j.jtct.2020.10.015