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Modification of the Pulmonary MyD88 Inflammatory Response Underlies the Role of the Yersinia pestisPigmentation Locus in Primary Pneumonic Plague
- Source :
- Infection and Immunity; December 2020, Vol. 89 Issue: 3
- Publication Year :
- 2020
-
Abstract
- Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing bronchopneumonia involving focal bacterial growth, neutrophilic congestion, and alveolar necrosis. Within a short time after inhalation of Y. pestis, inflammatory cytokines are expressed via the Toll/interleukin-1 (IL-1) adaptor myeloid differentiation primary response 88 (MyD88), which facilitates the primary lung infection.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 89
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs55358485
- Full Text :
- https://doi.org/10.1128/IAI.00595-20