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Clinical Outcomes in Patients with FLT3-ITD-Mutated Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Hematopoietic Stem Cell Transplantation after Quizartinib or Salvage Chemotherapy in the QuANTUM-R Trial

Authors :
Ganguly, Siddhartha
Cortes, Jorge E.
Krämer, Alwin
Levis, Mark J.
Martinelli, Giovanni
Perl, Alexander E.
Russell, Nigel H.
Arunachalam, Meena
Santos, Cedric Dos
Gammon, Guy
Lesegretain, Arnaud
Mires, Derek E.
Pham, Hoang
Wang, Yibin
Khaled, Samer K.
Source :
Transplantation and Cellular Therapy; February 2021, Vol. 27 Issue: 2 p153-162, 10p
Publication Year :
2021

Abstract

•Quizartinib enabled more patients to undergo hematopoietic stem cell transplantation (HSCT) versus chemotherapy.•Continuation of quizartinib after HSCT was tolerable, with no new safety signals.•Quizartinib before and after HSCT may confer clinical benefits in relapsed/refractory FLT3-ITD acute myelogenous leukemia.

Details

Language :
English
ISSN :
26666375 and 26666367
Volume :
27
Issue :
2
Database :
Supplemental Index
Journal :
Transplantation and Cellular Therapy
Publication Type :
Periodical
Accession number :
ejs55431739
Full Text :
https://doi.org/10.1016/j.bbmt.2020.09.036