Sesquiterpenoids from Chrysanthemum indicumwith Inhibitory Effects on NO Production

Three new guaianolide lactones (1–3) and four new 9-oxonerolidol glucosides (5–8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1–4and 15and flavones 17and 18exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50values in the range 0.2–27.0 μM.