A Retrospective Analysis of 450 TP53Mutations in a Real Life Cohort of CLL from the French Innovative Leukemia Organization (FILO) Group

In Chronic Lymphocytic Leukemia (CLL), it is well established that 17p deletions are associated with adverse prognosis and chemotherapy resistance. 17p deletions are most often associated with TP53mutations, but TP53mutations can occur in the absence of 17p deletion in about half of the cases with a similar unfavorable prognostic influence. Some patients harbor several subclones with different TP53mutations. Nonetheless, little is known on the functional effect of the various alterations and of their associations.