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Functional and Molecular Consequences of the Dnmt3aR882HMutation in Acute Myeloid Leukaemia
- Source :
- Blood; December 2015, Vol. 126 Issue: 23 p2424-2424, 1p
- Publication Year :
- 2015
-
Abstract
- The de novo DNA Methyltransferase 3A (DNMT3A) gene is one of the most commonly mutated gene in acute myeloid leukaemia with a normal karyotype (AML-NK). Approximately two thirds of mutations are heterozygous and affect codon R882, located within the methytransferase domain. Also, we and others have shown that these mutations occur in a significant proportion of haematologically normal people and behave as leukaemia-initiating changes.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 126
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs56862076
- Full Text :
- https://doi.org/10.1182/blood.V126.23.2424.2424