Multiple Myeloma Cells Induce Mitochondrial Stress Response in Bone Marrow Mesenchymal Stromal Cells

Introduction:Interaction of multiple myeloma (MM) cells with the surrounding bone marrow mesenchymal stromal cells (BMMSCs) is crucial for MM proliferation and survival. We have previously reported that in vitro cultured MM-BMMSCs display premature stress-induced senescence and constitutive changes in gene expression (Blood, 2013). Because mitochondrial oxidative stress could be the reason for senescence in MM-BMMSCs we investigated the metabolic interplay between MM-BMMSCs and MM cells.