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SSBP2-CSF1RIs a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome
- Source :
- Blood; November 2014, Vol. 124 Issue: 21 p3773-3773, 1p
- Publication Year :
- 2014
-
Abstract
- BCR-ABL1-like acute lymphoblastic leukaemia (ALL) is a subgroup of B cell precursor (BCP) ALL, which has a similar gene expression profile to BCR-ABL1positive ALL and shares the same high risk of relapse. BCR-ABL1-like ALL is genetically heterogeneous and no single abnormality defines them. However a number of novel fusion genes have been reported in this subgroup, which involve the kinase genes: PDGFRB, CSF1R, ABL1, ABL2and JAK2. Studies have shown that patients with these fusions may also respond to tyrosine kinase inhibitors (TKI), such as imatinib. Here we present a subset of patients with the SSBP2-CSF1Rfusion, including a patient treated with imatinib after relapse.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 124
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs56882281
- Full Text :
- https://doi.org/10.1182/blood.V124.21.3773.3773