Mucosal Foxp3+Regulatory T Cells Show Significant Numerical Differences in Patients with Intestinal Graft-Versus-Host Disease Compared to Infectious Diseases of the Gut.

Objectives: The clinical diagnosis of intestinal GvHD is often complicated, even if bioptical material is present. So far, it is difficult to separate between GvHD and infectious complications, since distinguishing immunological features are not established. In a multicenter study, we quantified Foxp3+immunoregulatory T cells (Treg) and effector T cells in the intestinal mucosa of patients with acute or chronic GvHD, and infectious diseases of the gut.