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Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of EnterobacteralesExpressing Extended-Spectrum β-Lactamases and Serine Carbapenemases
- Source :
- Antimicrobial Agents and Chemotherapy; July 2021, Vol. 65 Issue: 8
- Publication Year :
- 2021
-
Abstract
- There is an urgent need for oral agents to combat resistant Gram-negative pathogens. Here, we describe the characterization of VNRX-5236, a broad-spectrum boronic acid β-lactamase inhibitor (BLI), and its orally bioavailable etzadroxil prodrug, VNRX-7145.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 65
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57064044
- Full Text :
- https://doi.org/10.1128/AAC.00552-21