Inhibition of Herpes Simplex Virus Replication by Phosphonoacetic Acid

Authors :: Overby, L. R.
Robishaw, E. E.
Schleicher, J. B.
Rueter, A.
Shipkowitz, N. L.
Mao, J. C.-H.
Source :: Antimicrobial Agents and Chemotherapy; September 1974, Vol. 6 Issue: 3 p360-365, 6p
Publication Year :: 1974
Abstract: Replication of herpes simplex virus in WI-38 cells was inhibited by phosphonoacetic acid, as measured by decreased virus cytopathogenic effect and incorporation of radiolabeled thymidine in virus-infected cells. The drug appeared to have no effect on adsorption, penetration, or release of the virus nor on the synthesis of ribonucleic acid or protein. It appeared to inhibit virus deoxyribonucleic acid synthesis.