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7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase
- Source :
- Antimicrobial Agents and Chemotherapy; November 1982, Vol. 22 Issue: 5 p824-831, 8p
- Publication Year :
- 1982
-
Abstract
- Aminoglycoside-2"-O-adenylyltransferase was inhibited by 7-hydroxytropolone. Inhibition was competitive with respect to the cosubstrate ATP and appeared to require the unique vicinal arrangement of oxygens found in 7-hydroxytropolone. Combinations of 7-hydroxytropolone plus the appropriate aminoglycoside substrates were active against resistant bacteria possessing the adenylyltransferase. No potentiation was observed against other aminoglycoside-resistant or -susceptible strains. The fact that the inhibition of an aminoglycoside-modifying enzyme overcomes the poor uptake of aminoglycosides in resistant strains points to the singular importance of the inactivating enzyme as a determinant of resistance.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 22
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57123855
- Full Text :
- https://doi.org/10.1128/AAC.22.5.824