Molecular Basis for Resistance of AcanthamoebaTubulins to All Major Classes of Antitubulin Compounds

Authors :: Henriquez, Fiona L.
Ingram, Paul R.
Muench, Stephen P.
Rice, David W.
Roberts, Craig W.
Source :: Antimicrobial Agents and Chemotherapy; March 2008, Vol. 52 Issue: 3 p1133-1135, 3p
Publication Year :: 2008
Abstract: ABSTRACTTubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoebaspp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

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