Hot Spots of Integrase Genotypic Changes Leading to HIV-2 Resistance to Raltegravir

Authors :: Charpentier, Charlotte
Roquebert, Bénédicte
Delelis, Olivier
Larrouy, Lucile
Matheron, Sophie
Tubiana, Roland
Karmochkine, Marina
Duval, Xavier
Chêne, Geneviève
Storto, Alexandre
Collin, Gilles
Bénard, Antoine
Damond, Florence
Mouscadet, Jean-François
Brun-Vézinet, Françoise
Descamps, Diane
Source :: Antimicrobial Agents and Chemotherapy; December 2010, Vol. 55 Issue: 3 p1293-1295, 3p
Publication Year :: 2010
Abstract: ABSTRACTWe studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.

Full Text Access

Tools