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Histological Features of Osteoarthritis in a State of Decompensation

Authors :
Minasov, Timur B.
Yakupova, Ekaterina R.
Ruziboev, Dilmurod
Vakhitov-Kovalevich, Ruslan M.
Khairutdinov, Ruslan F.
Dorofeev, Yuri
Maslova, Marina
Source :
Journal of Biomimetics, Biomaterials and Biomedical Engineering; June 2014, Vol. 20 Issue: 1 p51-58, 8p
Publication Year :
2014

Abstract

Degenerative pathology of the musculoskeletal system is one of the main reasons for decreased mobility in patients of the older age group. Increasing the life expectancy leads to predominance non-epidemic pathology in all developed countries. Therefore, degenerative diseases of musculoskeletal system have not only medical significance but also social significance. Objective is studying the morphological features of synovial environment of the decompensated osteoarthritic (OA) knee joint. Structural features of subchondral bone, hyaline cartilage of the femur and tibia, the articular capsule, menisci and ligamentous apparatus of the knee joint were studied in 64 patients who underwent total knee arthroplasty at the Department of Traumatology and Orthopedics Bashkirian State Medical University in the period from 2015 to 2020. Material selection, preparation of histological samples, staining with hematoxylin-eosin, microscopy was performed. Adaptive signs of articular cartilage of the femoral condyles manifest in the form of cartilage tissue rearrangement, which are most pronounced in the central zone of the cartilage. At the same time, the phenomena of decompensation and significant areas of destruction are noted. Also, the subchondral bone was replaced with connective tissue with subsequent sclerosis. This sclerosis subsequently led to the decompensation of structures of the hyaline cartilage in the deep and middle zones. Destructive and dystrophic processes were noted in the knee joint menisci. Articular cartilage was replaced with granulation tissue with subsequent invasion of blood vessels. Cruciate ligaments in patients with OA show signs of adaptation due to expansion of endothenonium layers between bundles of collagen fibers and an increase in the diameter of blood vessels.

Details

Language :
English
ISSN :
22969837 and 22969845
Volume :
20
Issue :
1
Database :
Supplemental Index
Journal :
Journal of Biomimetics, Biomaterials and Biomedical Engineering
Publication Type :
Periodical
Accession number :
ejs57246764