High-Grade B-Cell Lymphomas with MYC and BCL2 Translocations Lack Tumor-Associated Macrophages and PD-L1 Expression: A Possible Noninflamed Subgroup

Extensive molecular analysis of large B-cell lymphomas (LBCL) have provided basis for new concepts of lymphoma taxonomy. These include stages of differentiation, phenotype (cell of origin) as well as genotype (including, but not confined to gene rearrangements) and immune microenvironment. The importance of the tumor microenvironment has recently regained focus due to development of immune checkpoint-inhibitors such as PD1/PD-L1 inhibitors, and LBCL may according to the new subtypes be stratified as microenvironment “inflamed” or “non-inflamed”, which may hold prognostic as well as predictive value.