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Novel Insight into Multi-Hit Multiple Myeloma Based on “Two-Hit” Theory of Cancer Causation
- Source :
- Blood; November 2020, Vol. 136 Issue: 1, Number 1 Supplement 1 p47-48, 2p
- Publication Year :
- 2020
-
Abstract
- Background: Current definition of multi-hit multiple myeloma (MM) is based upon the number of high-risk cytogenetic abnormalities (CA). But we may overlook the influence of standard-risk CA and different concurrent patterns. In fact, standard-risk t(11;14) and del(13q) may bring extra danger when concurrent with other CA. And the concurrency of two secondary CA may do more harm to patients than that of one secondary CA with one primary CA. This study is to answer whether CA number or pattern exert an impact on outcomes of MM patients.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 136
- Issue :
- 1, Number 1 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs57339005
- Full Text :
- https://doi.org/10.1182/blood-2020-140909