Back to Search
Start Over
Interleukin-21 Inhibits HBV Replication in vitro
- Source :
- Antiviral Therapy; August 2015, Vol. 20 Issue: 6 p583-590, 8p
- Publication Year :
- 2015
-
Abstract
- Background Cytokines are crucial factors in the non-cytolytic antiviral process to inhibit HBV gene expression and replication. Interleukin (IL)-21 has been suggested to play an important role in HBV infection, but it remains unknown whether IL-21 can inhibit HBV replication or how it inhibits HBV replication.Methods In this study, we investigated the influence of IL-21 on HBV replication based on human hepatoma Huh7.93 cells co-cultured with human peripheral blood mononuclear cells (PBMCs) and the possible correlation among IL-21, interferon-?, tumour necrosis factor-a and IL-10.Results We demonstrated that the decrease of IL-21 expression and the increase of IL-10 expression in PBMCs could promote HBV replication in vitro. We further revealed that IL-21 is not only able to effectively suppress HBV replication directly but also reduce HBV replication by inhibition of IL-10 secretion.Conclusions Our results provide important evidence for the non-cytolytic antiviral mechanism mediated by cytokines and their interactions in chronic hepatitis B.
Details
- Language :
- English
- ISSN :
- 13596535
- Volume :
- 20
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Antiviral Therapy
- Publication Type :
- Periodical
- Accession number :
- ejs57466600
- Full Text :
- https://doi.org/10.3851/IMP2950