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Risk factors for loss of virological suppression in patients receiving lopinavir/ritonavir monotherapy for maintenance of HIV suppression

Authors :
Pulido, Federico
Pérez-Valero, Ignacio
Delgado, Rafael
Arranz, Alberto
Pasquau, Juan
Portilla, Joaquín
Rubio, Rafael
González-García, Juan
Miralles, Pilar
Pérez-Elías, Maria J
Ocampo, Antonio
Hernando, Asunción
Estrada, Vicente
Clotet, Bonaventura
Podzamczer, Daniel
Arribas, José R
Source :
Antiviral Therapy; February 2009, Vol. 14 Issue: 2 p195-201, 7p
Publication Year :
2009

Abstract

Background Risk factors for loss of virological response in patients receiving lopinavir/ritonavir (LPV/r) monotherapy as maintenance treatment have not been determined.Methods In 121 patients enrolled in the OK and OK04 clinical trials assigned to receive monotherapy with LPV/r, we attempted to identify factors associated with loss of virological suppression at 48 weeks, defined as confirmed serum HIV type-1 RNA>50 copies/ml, with missing data or changes caused by toxicity censored. Univariate and multivariate Cox proportional hazard models were used to calculate hazard ratios for the risk of loss of virological suppression.Results At week 48, 15 patients experienced loss of virological suppression. Probability of loss of virological suppression was 12.7%. Less than 9 months of maintenance of virological suppression prior to monotherapy, a lower baseline haemoglobin and low adherence measured by self-reported total missed doses in the week prior to study visit were associated with loss of virological suppression in the univariate analyses. Independent factors associated with loss of virological suppression by multivariate analyses were =2 visits with self-reported missed doses in the week prior to the study visit, a lower baseline haemoglobin and a nadir CD4+T-cell count <100 cells/µlConclusions Suboptimal adherence, lower baseline haemoglobin and a nadir CD4+T-cell count <100 cells/µl were the main risk factors for losing virological suppression in patients randomized to monotherapy with LPV/r.

Details

Language :
English
ISSN :
13596535
Volume :
14
Issue :
2
Database :
Supplemental Index
Journal :
Antiviral Therapy
Publication Type :
Periodical
Accession number :
ejs57468214
Full Text :
https://doi.org/10.1177/135965350901400210