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fhuAof Actinobacillus pleuropneumoniaeEncodes a Ferrichrome Receptor but Is Not Regulated by Iron
- Source :
- Infection and Immunity; May 2003, Vol. 71 Issue: 5 p2911-2915, 5p
- Publication Year :
- 2003
-
Abstract
- ABSTRACTThe swine pathogen Actinobacillus pleuropneumoniaepossesses a 75-kDa outer membrane protein (OMP), FhuA, the receptor for ferrichrome, a hydroxamate-type siderophore. Polyclonal serum to FhuA reacted with OMP preparations from 12 serotypes of A. pleuropneumoniaeunder conditions of iron repletion and restriction. Reverse transcription-PCR confirmed that A. pleuropneumoniae fhuAexpression is not upregulated in response to low iron levels. An A. pleuropneumoniae fhuAdeletion mutant was generated and showed abolishment of ferrichrome uptake.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 71
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs57556280
- Full Text :
- https://doi.org/10.1128/IAI.71.5.2911-2915.2003