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Low Postseroconversion CD4+T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection
- Source :
- mBio; January 2019, Vol. 10 Issue: 1
- Publication Year :
- 2019
-
Abstract
- The relationship between HIV evolution and disease progression is fundamental to our understanding of HIV immune control and vaccine design. There are no clear definitions for faster and slower HIV-2 disease progression and for the relationship of the rate of progression with HIV-2 evolution. To address the hypothesis that viral evolution is correlated with disease progression in HIV-2 infection, we determined faster and slower disease progression based on follow-up data from a prospective cohort of police officers in Guinea-Bissau. The analysis showed that although the CD4+T-cell level and the decline in the level were independently associated with progression to AIDS, only the CD4+T-cell level or a combined CD4+T-cell level/decline stratification was associated with the rate of HIV-2 evolution. The HIV-2 evolutionary rate was almost twice as high among the faster progressors as among the slower progressors. Importantly, this report defines previously unknown characteristics linking HIV-2 disease progression with virus evolution.
Details
- Language :
- English
- ISSN :
- 21612129 and 21507511
- Volume :
- 10
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- mBio
- Publication Type :
- Periodical
- Accession number :
- ejs57734909
- Full Text :
- https://doi.org/10.1128/mBio.01245-18