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Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae
- Source :
- mBio; April 2020, Vol. 11 Issue: 2
- Publication Year :
- 2020
-
Abstract
- In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K.pneumoniae. Here, we identified a new plasmid-borne RND-type tigecycline resistance determinant, TMexCD1-TOprJ1, which is widespread among K. pneumoniaeisolates from food animals. tmexCD1-toprJ1appears to have originated from the chromosome of a Pseudomonasspecies and may have been transferred onto plasmids by adjacent site-specific integrases. Although tmexCD1-toprJ1still appears to be rare in human clinical isolates, considering the transferability of the tmexCD1-toprJ1gene cluster and the broad substrate spectrum of TMexCD1-TOprJ1, further dissemination of this mobile tigecycline resistance determinant is possible. Therefore, from a “One Health” perspective, measures are urgently needed to monitor and control its further spread. The current low prevalence in human clinical isolates provides a precious time window to design and implement measures to tackle this.
Details
- Language :
- English
- ISSN :
- 21612129 and 21507511
- Volume :
- 11
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- mBio
- Publication Type :
- Periodical
- Accession number :
- ejs57735416
- Full Text :
- https://doi.org/10.1128/mBio.02930-19