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SMX-1 virus-induced inhibition of ecotropic and recombinant proviral sequence amplification in thymuses of AKR mice

Authors :
Buchhagen, D L
Stockert, E
Source :
The Journal of Virology; November 1984, Vol. 52 Issue: 2 p624-629, 6p
Publication Year :
1984

Abstract

SMX-1 virus delays the appearance of spontaneous thymomas in AKR mice which have been inoculated as young adults by the intrathymic route. Analyses of high-molecular-weight thymus DNAs from SMX-1 virus-inoculated AKR mice indicated the absence of 3' recombinant proviral-cellular DNA junction fragments generated by EcoRI and PvuII digestion. An average of five recombinant proviral fragments were detected in DNAs from spontaneous thymomas that developed in medium-injected control mice. Preleukemic mice that amplify murine leukemia virus-related antigens on their thymocyte surface contained unintegrated proviruses in their thymus DNAs, and 2.3-kilobase EcoRI and 2.1-kilobase PvuII recombinant DNA fragments were detected.

Details

Language :
English
ISSN :
0022538X and 10985514
Volume :
52
Issue :
2
Database :
Supplemental Index
Journal :
The Journal of Virology
Publication Type :
Periodical
Accession number :
ejs57745672
Full Text :
https://doi.org/10.1128/jvi.52.2.624-629.1984