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SMX-1 virus-induced inhibition of ecotropic and recombinant proviral sequence amplification in thymuses of AKR mice
- Source :
- The Journal of Virology; November 1984, Vol. 52 Issue: 2 p624-629, 6p
- Publication Year :
- 1984
-
Abstract
- SMX-1 virus delays the appearance of spontaneous thymomas in AKR mice which have been inoculated as young adults by the intrathymic route. Analyses of high-molecular-weight thymus DNAs from SMX-1 virus-inoculated AKR mice indicated the absence of 3' recombinant proviral-cellular DNA junction fragments generated by EcoRI and PvuII digestion. An average of five recombinant proviral fragments were detected in DNAs from spontaneous thymomas that developed in medium-injected control mice. Preleukemic mice that amplify murine leukemia virus-related antigens on their thymocyte surface contained unintegrated proviruses in their thymus DNAs, and 2.3-kilobase EcoRI and 2.1-kilobase PvuII recombinant DNA fragments were detected.
Details
- Language :
- English
- ISSN :
- 0022538X and 10985514
- Volume :
- 52
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- The Journal of Virology
- Publication Type :
- Periodical
- Accession number :
- ejs57745672
- Full Text :
- https://doi.org/10.1128/jvi.52.2.624-629.1984