Coding and Noncoding Genomic Regions of Entamoeba histolyticaHave Significantly Different Rates of Sequence Polymorphisms: Implications for Epidemiological Studies

ABSTRACTTo evaluate genetic variability among Entamoeba histolyticastrains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.