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DNA-mediated transfer of a human DNA repair gene that controls sister chromatid exchange
- Source :
- Molecular and Cellular Biology; April 1985, Vol. 5 Issue: 4 p881-884, 4p
- Publication Year :
- 1985
-
Abstract
- The Chinese hamster cell line mutant EM9, which has a reduced ability to repair DNA strand breaks, is noted for its highly elevated frequency of sister chromatid exchange, a property shared with cells from individuals with Bloom's syndrome. The defect in EM9 cells was corrected by fusion hybridization with normal human fibroblasts and by transfection with DNA from hybrid cells. The transformants showed normalization of sister chromatid exchange frequency but incomplete correction of the repair defect in terms of chromosomal aberrations produced by 5-bromo-2'-deoxyuridine.
Details
- Language :
- English
- ISSN :
- 02707306 and 10985549
- Volume :
- 5
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Molecular and Cellular Biology
- Publication Type :
- Periodical
- Accession number :
- ejs57789736
- Full Text :
- https://doi.org/10.1128/mcb.5.4.881-884.1985