3-DIMENSIONAL CARDIOGENIC SHOCK SIMULATOR PHASE I: SUCCESSFUL DEVELOPMENT OF A LARGE ANIMAL CARDIOGENIC SHOCK MODEL

Post-myocardial infarction (Post-MI) cardiogenic shock (CS) is a serious life-threatening condition that requires complex coordinated care. Despite this, early mortality remains as high as 50%, likely owing to still inadequate understanding of pathophysiology and the potential benefits of percutaneous ventricular assist devices (pVADs). Although all pVADs increase circulatory flow, they vary in their ability to help restore cardiac pump function. Additionally, shortcomings in terms of our understanding of the optimal timing of such devices in STEMI and shock algorithms likely contributes to the high mortality. Currently, preclinical pVAD evaluation is limited by the need for animal research where the induction of CS is often lethal before devices can be tested. We therefore plan to develop a high-fidelity simulator to facilitate device evaluation and help train clinical teams. The first phase to this program requires the elaboration of a stable animal post-MI CS model that can generate the physiologic data necessary for simulator validation.