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Metal-Free Cascade Formation of Intermolecular C–N Bonds Accessing Substituted Isoindolinones under Cathodic Reduction
- Source :
- The Journal of Organic Chemistry; November 2021, Vol. 86 Issue: 21 p15777-15784, 8p
- Publication Year :
- 2021
-
Abstract
- An electrochemical protocol for the construction of substituted isoindolinones via reduction/amidation of 2-carboxybenzaldehydes and amines has been realized. Under metal-free and external-reductant-free electrolytic conditions, the reaction achieves the cascade formation of intermolecular C–N bonds and provides a series of isoindolinones in moderate to good yields. The deuterium-labeling experiment proves that the hydrogen in the methylene of the product is mainly provided by H2O in the system.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 86
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- The Journal of Organic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs58122705
- Full Text :
- https://doi.org/10.1021/acs.joc.1c01845