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Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway

Authors :
Hua, Kuo-Feng
Chao, A-Ching
Lin, Ting-Yu
Chen, Wan-Tze
Lee, Yu-Chieh
Hsu, Wan-Han
Lee, Sheau-Long
Wang, Hsin-Min
Yang, Ding-I.
Ju, Tz-Chuen
Source :
Journal of Ginseng Research; 20210101, Issue: Preprints
Publication Year :
2021

Abstract

Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of trinucleotide CAG repeat in the Huntingtin (Htt) gene. The major pathogenic pathways underlying HD involve the impairment of cellular energy homeostasis and DNA damage in the brain. The protein kinase ataxia-telangiectasia mutated (ATM) is an important regulator of the DNA damage response. ATM is involved in the phosphorylation of AMP-activated protein kinase (AMPK), suggesting that AMPK plays a critical role in response to DNA damage. Herein, we demonstrated that expression of polyQ-expanded mutant Htt (mHtt) enhanced the phosphorylation of ATM. Ginsenoside is the main and most effective component of Panax ginseng. However, the protective effect of a ginsenoside (compound K, CK) in HD remains unclear and warrants further investigation.

Details

Language :
English
ISSN :
12268453 and 20934947
Issue :
Preprints
Database :
Supplemental Index
Journal :
Journal of Ginseng Research
Publication Type :
Periodical
Accession number :
ejs58250764
Full Text :
https://doi.org/10.1016/j.jgr.2021.11.003