Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromycessp. HDN1820200

Six new nonadride derivatives, named talarodrides A–F (1–6), were isolated from the Antarctic sponge-derived fungus Talaromycessp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1–4share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5and 6possess the first case of a naturally occurring 5/7/6 methanocyclonona[c]furan skeleton. Talarodride A (1) and talarodride B (2) showed selective inhibitory effects against Proteus mirabilisand Vibrio parahemolyticuswith MICs of 3.13–12.5 μM.