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Preliminary application of brachytherapy with double-strand 125I seeds and biliary drainage for malignant obstructive jaundice

Authors :
Li, Zong-Ming
Jiao, De-Chao
Han, Xin-Wei
Lei, Qin-Yu
Zhou, Xue-Liang
Xu, Miao
Source :
Surgical Endoscopy; July 2022, Vol. 36 Issue: 7 p4932-4938, 7p
Publication Year :
2022

Abstract

Aim: To evaluate the efficacy and safety of brachytherapy with double-strand <superscript>125</superscript>I seeds and biliary drainage for malignant obstructive jaundice. Methods and Materials: 42 patients with obstructive jaundice because of extrahepatic cholangiocarcinoma were enrolled. 22 patients (group A) received a biliary stent with common drainage tube implantation, and 20 patients (group B) received a biliary stent with double-strand <superscript>125</superscript>I seeds radiotherapy drainage tube placement. The length, location and pathological stage of biliary stricture were recorded in the two groups. Total bilirubin (TBIL), direct bilirubin (DBIL), IgA, IgG, IgM, alanine aminotransferase and white blood cell (WBC) count were measured before and after percutaneous transhepatic cholangial drainage (PTCD). Tumor diameter was measured before and three months after PTCD, and the difference were calculated. Stent patency time, survival time, and complications were recorded. Results: There was no significant difference in the length, location and pathological stage of biliary stenosis between the two groups. There was no significant difference in TBIL, DBIL, IgA, IgG, IgM, alanine aminotransferase and WBC count between the two groups before or after PTCD (P> 0.05). Three months after PTCD, tumors growth in group A and tumors shrinkage in group B. The difference in tumor size between the two groups before and after PTCD was statistically significant (P< 0.05). The average stent patency times in groups A and B were 3.55 ± 0.76 months and 8.76 ± 1.85 months, respectively (P< 0.05). The average survival times in groups A and B were 133.5 ± 27.8 days and 252.5 ± 114.5 days, respectively (P< 0.05). There was no statistically significant difference in the incidence of complications between the two groups (P> 0.05). Conclusion: Double-strand <superscript>125</superscript>I seeds radiotherapy biliary drainage tubes can safely and effectively control tumors, prolong the patency of biliary stents, and prolong patient survival.

Details

Language :
English
ISSN :
09302794 and 14322218
Volume :
36
Issue :
7
Database :
Supplemental Index
Journal :
Surgical Endoscopy
Publication Type :
Periodical
Accession number :
ejs58374890
Full Text :
https://doi.org/10.1007/s00464-021-08848-6