Back to Search
Start Over
Rifamycin resistance, rpoBgene mutation and clinical outcomes of Staphylococcusspecies isolates from prosthetic joint infections in Republic of Korea
- Source :
- Journal of Global Antimicrobial Resistance; March 2022, Vol. 28 Issue: 1 p43-48, 6p
- Publication Year :
- 2022
-
Abstract
- •In vitro activities of rifamycins against planktonic and biofilm Staphylococcusspp. isolates from PJIs.•rpoBgene mutations were analysed and clinical outcomes of rifampicin-resistant isolates were characterised.•Isolates comprised 85 S. aureus(55% methicillin-resistant) and 25 S. epidermidis(100% methicillin-resistant).•Seven S. aureusisolates and two S. epidermidisisolates were rifampicin-resistant and these exhibited rpoBgene mutations.•Rifamycins other than rifampicin showed promising antistaphylococcal activity, including antibiofilm activity.•Rifampicin-resistant isolates had poor clinical outcomes.
Details
- Language :
- English
- ISSN :
- 22137165
- Volume :
- 28
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Global Antimicrobial Resistance
- Publication Type :
- Periodical
- Accession number :
- ejs58480063
- Full Text :
- https://doi.org/10.1016/j.jgar.2021.12.005