Rifamycin resistance, rpoBgene mutation and clinical outcomes of Staphylococcusspecies isolates from prosthetic joint infections in Republic of Korea

•In vitro activities of rifamycins against planktonic and biofilm Staphylococcusspp. isolates from PJIs.•rpoBgene mutations were analysed and clinical outcomes of rifampicin-resistant isolates were characterised.•Isolates comprised 85 S. aureus(55% methicillin-resistant) and 25 S. epidermidis(100% methicillin-resistant).•Seven S. aureusisolates and two S. epidermidisisolates were rifampicin-resistant and these exhibited rpoBgene mutations.•Rifamycins other than rifampicin showed promising antistaphylococcal activity, including antibiofilm activity.•Rifampicin-resistant isolates had poor clinical outcomes.