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Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)
- Source :
- Thorax; 2022, Vol. 77 Issue: 1 p79-81, 3p
- Publication Year :
- 2022
-
Abstract
- Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.
Details
- Language :
- English
- ISSN :
- 00406376 and 14683296
- Volume :
- 77
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Thorax
- Publication Type :
- Periodical
- Accession number :
- ejs58512491
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2021-217362