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Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)

Authors :
van Oort, Pouline MP
Nijsen, Tamara M
White, Iain R
Knobel, Hugo H
Felton, Timothy
Rattray, Nicholas
Lawal, Oluwasola
Bulut, Murtaza
Ahmed, Waqar
Artigas, Antonio
Povoa, Pedro R
Martin-Loeches, Ignacio
Weda, Hans
Goodacre, Royston
Schultz, Marcus J
Dark, Paul M
Fowler, Stephen J
Bos, Lieuwe D
Source :
Thorax; 2022, Vol. 77 Issue: 1 p79-81, 3p
Publication Year :
2022

Abstract

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.

Details

Language :
English
ISSN :
00406376 and 14683296
Volume :
77
Issue :
1
Database :
Supplemental Index
Journal :
Thorax
Publication Type :
Periodical
Accession number :
ejs58512491
Full Text :
https://doi.org/10.1136/thoraxjnl-2021-217362