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TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis

Authors :
Bernal-Martínez, L
Gonçalves, SM
de Andres, B
Cunha, C
Gonzalez Jimenez, I
Lagrou, K
Mellado, E
Gaspar, ML
Maertens, JA
Carvalho, A
Alcazar-Fuoli, L
Source :
Virulence; December 2021, Vol. 12 Issue: 1 p570-583, 14p
Publication Year :
2021

Abstract

ABSTRACTPattern recognition receptors (PRRs) are responsible for Aspergillus fumigatusrecognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils and macrophages. A soluble form (sTREM1) of this protein that can be detected in human body fluids has been identified. Here we investigated the role of TREM1 during invasive pulmonary aspergillosis (IPA). IPA patients displayed significantly higher levels of sTREM1 in bronchoalveolar lavages when compared to control patients. Functional analysis in TREM1 showed that the levels of sTREM1 and TREM1 pathway-related cytokines were influenced by single nucleotide polymorphisms in TREM1. In addition, we confirmed a role of TREM1 on antifungal host defense against A. fumigatusin a murine model of IPA. TREM1 deficiency increased susceptibility to infection in the immunosuppressed murine host. Deletion of TREM1 showed delayed innate and adaptive immune responses and impaired pro-inflammatory cytokine responses. The absence of TREM1 in primary macrophages attenuated the TLR signaling by altering the expression of both receptor and effector proteins that are critical to the response against A. fumigatus. In this study, and for the first time, we demonstrate the key role for the TREM1 receptor pathway during IPA.

Details

Language :
English
ISSN :
21505594 and 21505608
Volume :
12
Issue :
1
Database :
Supplemental Index
Journal :
Virulence
Publication Type :
Periodical
Accession number :
ejs58572110
Full Text :
https://doi.org/10.1080/21505594.2021.1879471