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Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
- Source :
- Gut Microbes; January 2021, Vol. 13 Issue: 1
- Publication Year :
- 2021
-
Abstract
- ABSTRACTReduction of A. muciniphilarelative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at identifying metabolic signatures associated with beneficial properties of alive and pasteurized A. muciniphilawhen administrated to a cohort of insulin-resistant individuals with metabolic syndrome. Our data highlighted either shared or specific alterations in the metabolome according to the form of A. muciniphilaadministered with respect to a control group. Common responses encompassed modulation of amino acid metabolism, characterized by reduced levels of arginine and alanine, alongside several intermediates of tyrosine, phenylalanine, tryptophan, and glutathione metabolism. The global increase in levels of acylcarnitines together with specific modulation of acetoacetate also suggested induction of ketogenesis through enhanced β-oxidation. Moreover, our data pinpointed some metabolites of interest considering their emergence as substantial compounds pertaining to health and diseases in the more recent literature.
Details
- Language :
- English
- ISSN :
- 19490976 and 19490984
- Volume :
- 13
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Gut Microbes
- Publication Type :
- Periodical
- Accession number :
- ejs58593480
- Full Text :
- https://doi.org/10.1080/19490976.2021.1994270