Post-transplant day +100 MRD detection rather than mixed chimerism predicts relapses after allo-SCT for intermediate risk AML patients transplanted in CR

•full donor chimerism can mitigate negative impact of pre-transplant MRD positivity•qPCR-MRD is more predictive for post-transplant relapse than MFC-MRD•mixed chimerism has limited predictive value for post-transplant relapses•mixed chimerism without post-transplant MRD is not associated with worse outcomes