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δ-C–H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor
- Source :
- Organic Letters; May 2022, Vol. 24 Issue: 20 p3652-3656, 5p
- Publication Year :
- 2022
-
Abstract
- Nitrogen-centered radicals are versatile synthetic intermediates with the ability to undergo diverse reactions such as hydrogen atom transfer (HAT), β-scission, and addition across unsaturated systems. A long-standing impediment to the wider adoption of these intermediates in synthesis has been the difficulty of their generation. Herein we disclose a new hydrazonyl carboxylic acid precursor to nitrogen-centered radicals and its application toward remote C–H fluorination and chlorination reactions of sulfonyl-protected alkyl amines via 1,5-HAT.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 24
- Issue :
- 20
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs59661194
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c01261